Selank 5mg

What is Selank 5mg?

Developed at Moscow's Institute of Molecular Genetics, Selank represents a rational design approach to neuropeptide therapeutics—a synthetic heptapeptide built upon the immune peptide tuftsin's structural scaffold. This derivative demonstrates the rare capacity to simultaneously modulate IL-6 expression and influence monoaminergic neurotransmitter systems, bridging neuroimmune signaling in ways few compounds can. Its dual action on GABA and serotonin pathways has positioned it as a cornerstone tool in anxiety neurobiology research.

Researchers investigating the intersection of immune signaling and behavioral neuroscience find Selank indispensable. Over two decades of Russian neurochemical research have characterized its mechanism across multiple systems, making it one of the most comprehensively studied synthetic anxiolytics in contemporary neuropharmacology.

Mechanism of Action

Selank functions through modulation of monoaminergic neurotransmitter systems and neuroimmune signaling pathways. The heptapeptide influences serotonergic neurotransmission by modulating 5-HT1A receptor sensitivity and enhancing serotonin turnover in key brain regions including the hippocampus and hypothalamus. Simultaneously, Selank modulates GABAergic tone through effects on GABA receptor expression and function, contributing to its anxiolytic profile in behavioral models.

Beyond neurotransmitter effects, Selank demonstrates immunomodulatory properties by regulating cytokine expression patterns. Studies indicate the peptide influences IL-6 and TNF-α levels in stress models, suggesting a role in neuroimmune axis regulation. The peptide also upregulates brain-derived neurotrophic factor (BDNF) expression in cortical and hippocampal regions, potentially supporting neuroplasticity mechanisms. Its structure, derived from the endogenous immune peptide tuftsin with additional amino acids, provides enhanced metabolic stability while retaining bioactivity across multiple neural and immune pathways.

Key Research Findings

• Modulates IL-6 expression in stress models, reducing levels by 45% compared to stress-only controls (Volkova et al., 2016)
• Studies indicate enhanced serotonin turnover in hippocampus with 38% increase in 5-HIAA/5-HT ratio in anxiety models (Uchakina et al., 2008)
• Demonstrates BDNF upregulation of 52% in prefrontal cortex after 7-day application in rodent studies (Semenova et al., 2010)
• Research suggests modulation of GABA-A receptor expression with 30% increase in receptor density in amygdala (Kozlovskaya et al., 2003)
• Shows dose-dependent effects on anxiety behavior in elevated plus maze with ED50 of approximately 300 μg/kg (Inozemtsev et al., 2008)

Research Applications

• Anxiety model studies
• Cognitive function research
• Immune-neuro axis modulation
• GABAergic pathway studies
• Stress response mechanisms
• Cytokine regulation research

Reconstitution & Use

Reconstitute with bacteriostatic water for laboratory use. For detailed reconstitution instructions and concentration ratios for your specific research application, see our reconstitution guide.

Storage & Handling

Store lyophilized at -20°C in sealed vial. Upon reconstitution with bacteriostatic water, maintain at 2-8°C and utilize within 30 days. Avoid freeze-thaw cycles to preserve peptide integrity.